Application
Immunofluorescence of CDNF in Human Brain cells with CDNF antibody at 20 ug/mL.Application
Western blot analysis of CDNF in A-20 cell lysate in (A) the absence and (B) the presence of blocking peptide with CDNF antibody at 1 ug/ml.Application
Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 5 ug/ml.| Product Name | CDNF antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to CDNFThe conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson’s disease. At least two isoforms of CDNF are known to exist. This antibody does not cross-react with MANF. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | ARMETlike1 mutated in early stage tumors-like 1 mutated in early stage tumorslike1 ARMET-like 1 mutated in early stage tumorslike 1 Conserved dopamine neurotrophic factor arginine-rich ARMETlike 1 CDNF ARMETL1 argininerich ARMET like 1 arginine |
|---|---|
| Target | CDNF |
| Tissue Specificity | This antibody is specific for CDNF N-Terminus |
Application
Immunofluorescence of CDNF in Human Brain cells with CDNF antibody at 20 ug/mL.
Application
Western blot analysis of CDNF in A-20 cell lysate in (A) the absence and (B) the presence of blocking peptide with CDNF antibody at 1 ug/ml.
Application
Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 5 ug/ml.| Positive Control | Blocking Peptide: |
|---|---|
| Application Notes | ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
