| Product Name | CHERP antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to CHERPThe Calcium homoeostasis endoplasmic reticulum protein (CHERP) gene has been recently identified and localized on chromosome 19p13.1. CHERP has high homology to an SR related CTD protein, which is known to interact with the largest subunit of RNA polymerase II. CHERP is an integral endoplasmic reticulum membrane protein is involved in calcium mobilization induced by thrombin. Confocal microscopy revealed that CHERP is associated with Ins(1,4,5)P3 receptor throughout the cytoplasm and perinuclear region in Jurkat T lymphocyte. CHERP Anti sense treatment induced a decrease in CHERP, whichv caused an impaired increase in free cytoplasmic calcium but calcium influx remains unaffected, with some deficient in endoplasmic reticulum calcium stores. In the CHERP depleted Jurkat T lymphocytes the calcium dependent translocation of nuclear factor of activated T cells (NFAT) from cytoplasm to nucleus was also suppressed with significant suppression of cell. |
| Immunogen | Synthetic peptides, post synthetically modified to achieve desired antigenicty. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIPWB |
| ICC: Use at a dilution of 1/200. IP: Use at a dilution of 1/200. WB: Use at a dilution of 1/500. Predicted molecular weight: 106 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Gene Synonyms | SCAF6 10523 Q8IWX8 CHERP DAN16 SRA1 |
|---|---|
| Target | CHERP |
| Cellular Localization | Endoplasmic reticulum |
| Positive Control | CHERP mRNA is expressed ubiquitously in various tissues including lung, brain, heart, pancreas, kidney and skeletal muscle. |
|---|---|
| Application Notes | ICC: Use at a dilution of 1/200. IP: Use at a dilution of 1/200. WB: Use at a dilution of 1/500. Predicted molecular weight: 106 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20ºC |
| Storage Buffer | Antibody stabilization buffer. |
