Rabbit Polyclonal antibody to CHIT1Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Immunogen
The immunogen sequences we used to generate this item is C-terminal 250AA in the full length.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIHC-PWB
WB 1:500 - 1:2000, IHC 1:50 - 1:200:
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
chitinase 1 (chitotriosidase) CHI3 CHIT CHITD
Target
CHIT1
Molecular Weight(MW)
52 kDa (note)
Application
Application
Western blot analysis of extracts of various cells, using CHIT1 antibody.
Application
Immunohistochemistry of paraffin-embedded human normal stomach using CHIT1 antibody at dilution of 1:200 (400x lens).