Application
Sample (30 ug of whole cell lysate) A: U87-MG B: MCF-7 10% SDS PAGE diluted at 1:500| Product Name | CHRFAM7A antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to CHRFAM7A (CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion)The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CHRFAM7A. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICCIHCWB |
| *Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CHRNA7 antibody, CHRNA7-DR1 antibody, D-10 antibody, MGC120482 antibody, MGC120483 antibody, CHRFAM7A antibody, CHRNA7-FAM7A fusion protein antibody, alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid antibody, |
|---|---|
| Molecular Weight(MW) | 46 kDa (note) (2) |
| Cellular Localization | Membrane |
Application
Sample (30 ug of whole cell lysate) A: U87-MG B: MCF-7 10% SDS PAGE diluted at 1:500| Positive Control | NT2D1 , U87-MG , MCF-7 |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
