Application
Immunofluorescence of CIITA in human brain tissue with CIITA antibody at 20 ug/mL.Application
Western blot analysis of CIITA in mouse brain tissue lysate with CIITA antibody at 1 ug/mL.Application
Immunohistochemistry of CIITA in human brain tissue with CIITA antibody at 10 ug/mL.| Product Name | CIITA antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to CIITAThis gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| Immunogen | CIITA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CIITA. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| IF: 20 ug/mL | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | CIITAIV , NLRA , C2TA , MHC2TA , class II, major histocompatibility complex, transactivator |
|---|---|
| Target | CIITA |
Application
Immunofluorescence of CIITA in human brain tissue with CIITA antibody at 20 ug/mL.
Application
Western blot analysis of CIITA in mouse brain tissue lysate with CIITA antibody at 1 ug/mL.
Application
Immunohistochemistry of CIITA in human brain tissue with CIITA antibody at 10 ug/mL.| Application Notes | IF: 20 ug/mL |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Be stored at 4oC for three months and -20oC, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | PBS containing 0.02% sodium azide. |
