Application
Immunohistochemistry of CIP75 in mouse kidney tissue with CIP75 antibody at 5 ug/ml.Application
Western blot analysis of CIP75 in 3T3 cell lysate with CIP75 antibody at (A) 1 and (B) 2 ug/ml.| Product Name | CIP75 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to CIP75The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CIP75, Connexin43interatcting protein75, UBIN, Ataxin1 ubiquitinlikeinteracting protein, Ataxin-1 ubiquitin-like-interacting protein, A1U, UBQLN4, Connexin43interatcting protein 75, ubiquilin-4, Connexin-43-interatcting protein 75, ubiquilin4, ubiquilin 4 |
|---|---|
| Target | CIP75 |
| Tissue Specificity | This antibody is specific for CIP75 |
Application
Immunohistochemistry of CIP75 in mouse kidney tissue with CIP75 antibody at 5 ug/ml.
Application
Western blot analysis of CIP75 in 3T3 cell lysate with CIP75 antibody at (A) 1 and (B) 2 ug/ml.| Positive Control | Blocking Peptide: Cat.No. GTX85267-PEP - CIP75 Peptide Lysates: Cat. No. GTX27901 - 3T3 (NIH) Cell Lysate |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
