Application
Western blot analysis of c-Jun p39 expression in Jurkat whole cell lysates.| Product Name | c-Jun antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to c - Junc-Jun (previously known as the Fos-binding protein p39) and c-Fos form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP-1-binding site (1). AP-1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). Fos and Jun proto-oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Fos has a unique role in determining the differentiation and activity of progenitors of the osteoclast lineage (4). A mutated version of c-Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds, probably from transcriptional deregulation of v-Jun-responsive target genes (7). |
| Immunogen | Synthetic peptide (Mouse) (N terminal). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-FIPWB |
| Species Reactivity | HumanMouseRat |
| Concentration | 0.2mg/ml |
| Purification | Unpurified |
| Gene Synonyms | cJun, JUN, AP1, 165160, c-jun, Junc, P05412, 3725, AP-1, 16476, c Jun, AP 1 |
|---|---|
| Target | c-Jun |
| Tissue Specificity | Reacts with c-Jun p39 |
| Cellular Localization | Nuclear |
Application
Western blot analysis of c-Jun p39 expression in Jurkat whole cell lysates.| Positive Control | NIH/3T3 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment. |
| Storage Buffer | PBS with 0.1% sodium azide |
