Application
Western blot analysis of CKIP1 in human lung tissue lysate with CKIP1 antibody at (A) 1 and (B) 2 ug/ml.| Product Name | CKIP1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to CKIP1CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha’, and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | family O member 1, PLECKHO1, Casein kinase2interacting protein 1, CKIP1, pleckstrin homology domain containing, Casein kinase-2-interacting protein 1, Casein kinase2interacting protein1, family O member1 |
|---|---|
| Target | CKIP1 |
| Tissue Specificity | This antibody is specific for CKIP1 |
Application
Western blot analysis of CKIP1 in human lung tissue lysate with CKIP1 antibody at (A) 1 and (B) 2 ug/ml.| Positive Control | Blocking Peptide: Cat.No. GTX85240-PEP - CKIP1 Peptide Lysates: Cat. No. GTX27917 - Human Lung Tissue Lysate |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
