Application
WB analysis of PC-3 lysate using Claudin 11 antibody.Application
ICC/IF analysis of U2OS cells using Claudin 11 antibody (red) and DAPI (blue).Application
IHC-P analysis of human kidney cancer using Claudin 11 antibody at a dilution of 1:200.| Product Name | Claudin 11 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Claudin 11This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010] |
| Immunogen | Recombinant protein of human CLDN11 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHC-PWB |
| WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200: |
|
| Species Reactivity | HumanMouseRabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | OTM OSP claudin 11 CLDN11 |
|---|---|
| Target | Claudin 11 |
| Molecular Weight(MW) | 22 kDa (note) |
Application
WB analysis of PC-3 lysate using Claudin 11 antibody.
Application
ICC/IF analysis of U2OS cells using Claudin 11 antibody (red) and DAPI (blue).
Application
IHC-P analysis of human kidney cancer using Claudin 11 antibody at a dilution of 1:200.| Application Notes | WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
