| Product Name | Coagulation factor III/Tissue Factor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [TF9-10H10] to Tissue FactorThis gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| Immunogen | Denatured Tissue factor isolated from human brain by the Factor VII affinity method. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | TF9-10H10 |
| Host Species | Mouse |
| Tested Applications | FACSICC/IFIHC-FWB |
| FACS:1:200~1:500 ICC/IF:1:200~1:500 IHC-F:1:50~1:100 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanPrimate |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | TF TFA CD142 F3 |
|---|---|
| Target | CD142 |
| Tissue Specificity | This antibody recognizes both the reduced and native non-reduced human and primate tissue factors. It does not inhibit coagulation or neutralize factor VII binding to Tissue Factor. |
| Application Notes | FACS:1:200~1:500 ICC/IF:1:200~1:500 IHC-F:1:50~1:100 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.09% Sodium Azide (NaN3)200 mMMannitol |
