Application
Western blot analysis of Cox-3 with mouse small intestine tissue lysate.| Product Name | Cox-3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Cox-3COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been suggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. | |
| Species Reactivity | Mouse |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | PCOX1, PGHS1, PGHS-1, COX-3, PHS1, PTGS1, PTGHS, COX3, COX 3, PGHS 1 |
|---|---|
| Target | Cox-3 |
| Tissue Specificity | This antibody is specific for Cox-3. |
Application
Western blot analysis of Cox-3 with mouse small intestine tissue lysate.| Application Notes | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Stored at -20 °C for future use. |
| Storage Buffer | PBS (pH 7.2) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal |
