Rabbit Polyclonal antibody to COX7A2LCytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human COX7A2L
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB 1:500 - 1:2000
Species Reactivity
MouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
EB1 , SIG81 , COX7RP , cytochrome c oxidase subunit VIIa polypeptide 2 like , COX7AR
Target
COX7A2L
Molecular Weight(MW)
13 kDa (note)
Application
Application
Western blot analysis of extract of various cells, using COX7A2L antibody.