Rabbit Polyclonal antibody to CRB1This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Immunogen
The immunogen corresponding to a region within amino acids 651 and 700 of human CRB1.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAWB
WB: 1 - 2 ug/ml
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
crumbs homolog 1 (Drosophila) , LCA8 , RP12
Target
CRB1
Molecular Weight(MW)
142 kDa (note)
Tissue Specificity
Alternatively spliced transcript variants have been observed. CRB1 antibody i spredicted to not cross-react with CRB2.
Application
Application
Western blot analysis of CRB1 in human small intestine Tissue lysate with CRB1 antibody at 1 ug/mL.
Application Notes
WB: 1 - 2 ug/ml
Additional Information
Form
Liquid
Storage Instructions
CRB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Storage Buffer
CRB1 Antibody is supplied in PBS containing 0.02% sodium azide.