Rabbit Polyclonal antibody to CtIP (phospho Ser327)The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CTIP (pS327). The exact sequence is proprietary.
Modification
p-Ser327
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB: 1:500 - 1:1000
Species Reactivity
HumanMouse
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
RIM , COM1 , RBBP8 , SAE2 , SCKL2 , JWDS , CTIP , retinoblastoma binding protein 8
Target
CtIP (phospho Ser327)
Tissue Specificity
Recognizes endogenous levels of CTIP (pS327) protein.
Application
Application
Western blot analysis of CTIP (pS327) expression in HEK293T (A); Raw264.7 (B) whole cell lysates.
Application Notes
WB: 1:500 - 1:1000
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4 °C. Upon delivery aliquot and store at -20 °C for one year. Avoid freeze/thaw cycles.
Storage Buffer
Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.