Rabbit Polyclonal antibody to CTLA4This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human CTLA4
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
WB 1:500 - 1:2000, IHC 1:50 - 1:200
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
ALPS5 , GSE , CELIAC3 , CD152 , GRD4 , cytotoxic T-lymphocyte-associated protein 4 , CTLA-4 , IDDM12 , CD
Target
CTLA4
Molecular Weight(MW)
25 kDa (note)
Application
Application
Western blot analysis of extracts of various cell lines, using CTLA4 antibody.