Rabbit polyclonal antibody to CUEDC1The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC1 (CUE domain-containing protein 1) is a 386 amino acid protein that contains one CUE domain, suggesting a possible role in protein trafficking and degradation pathways. Two isoforms of CUEDC1 exist due to alternative splicing events. Defects in the gene encoding CUEDC1 may be associated with early stage cervical cancer, implicating CUEDC1 as a potential tumor marker. CUEDC1 antibody will not cross-react with CUEDC2.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHC-PWB
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
CUE Domain-Containing Protein 1, CUEDC1, CUE DomainContaining Protein1, CUE DomainContaining Protein 1
Target
CUEDC1
Tissue Specificity
This antibody is specific for CUEDC1
Application
Application
Immunohistochemistry of CUEDC1 in human liver tissue with CUEDC1 antibody at 2 ug/ml.
Application
Western blot analysis of CUEDC1 in rat liver tissue lysate with CUEDC1 antibody at (A) 0.5 and (B) 1 ug/ml.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.