Application
Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 μg/mL.Application
Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 μg/mL.| Product Name | CXXC4 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to CXXC4CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4’s interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-P |
| ICC/IF:1:200~1:500 IHC-P:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CXXCtype zinc finger protein 4 IDAX CXXCtype zinc finger protein4 CXXC4 CXXC-type zinc finger protein 4 |
|---|---|
| Target | CXXC4 |
| Tissue Specificity | This antibody is specific for CXXC4 |
Application
Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 μg/mL.
Application
Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 μg/mL.| Positive Control | Blocking Peptide: Cat.No. GTX84996-PEP - CXXC4 Peptide Lysates: Cat. No. GTX27918 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | ICC/IF:1:200~1:500 IHC-P:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Antibody is supplied in PBS containing 0.02% sodium azide |
