| Product Name | CYB5R3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to CYB5R3 (cytochrome b5 reductase 3)This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. These two forms are resulted from alternative splicing of the gene. Mutations in this gene cause methemoglobinemias. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CYB5R3. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Predicted Reactivity | Human, Mouse, Rat, Zebrafish, Dog, Chicken, Rhesus Monkey, Chimpanzee, BovineHuman (100%), Mouse (89%), Rat (91%), Zebrafish (82%), Dog (94%), Chicken (80%), Rhesus Monkey (94%), Chimpanzee (97%), Bovine (92%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | B5R antibody DIA1 antibody CYB5R3 antibody NADH-cytochrome b5 reductase 3 membrane-bound form antibody NADH-cytochrome b5 reductase 3 soluble form antibody diaphorase-1 antibody NADH-cytochrome b5 reductase 3 antibody cytochrome b5 reductase 3 antib |
|---|---|
| Target | CYB5R3 |
| Molecular Weight(MW) | 34 kDa (note) |
| Cellular Localization | Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side , Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side , Isoform 2: Cytoplasm |
| Positive Control | Target recombinant protein |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
