| Product Name | Cyclin E antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [168] to Cyclin ECyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in Cyclin E protein have been implicated as indicators of worse prognosis in various cancers. |
| Immunogen | Recombinant full length protein (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | 168 |
| Host Species | Mouse |
| Tested Applications | IPWB |
| IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 50 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMonkey |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | CCNE1 CCNE P24864 898 123837 Cyclin E |
|---|---|
| Target | Cyclin E |
| Cellular Localization | Nuclear |
| Application Notes | IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 50 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.08% Sodium Azide; Constituents: PBS |
