| Product Name | CYP3A4 antibody , Internal |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4)Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide. |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CYP3A4. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Rat |
| Predicted Reactivity | Human, Rhesus Monkey, ChimpanzeeHuman (100%), Rhesus Monkey (94%), Chimpanzee (99%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CP33 antibody CP34 antibody CYP3A antibody CYP3A3 antibody CYPIIIA3 antibody CYPIIIA4 antibody HLP antibody MGC126680 antibody NF-25 antibody P450C3 antibody P450PCN1 antibody CYP3A4 antibody cytochrome P450 HLp antibody cytochrome P450 3A4 an |
|---|---|
| Molecular Weight(MW) | 57 kDa (note) |
| Cellular Localization | Endoplasmic reticulum membrane , Microsome membrane |
| Positive Control | *Rat liver microsome |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
