Rabbit polyclonal antibody to Cytokeratin 80Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Immunogen
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human Cytokeratin 80.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB : 1:1000
Species Reactivity
Human
Concentration
0.5mg/ml
Purification
Protein A
Target Information
Gene Synonyms
keratin 80 KB20
Target
KRT80
Application
Application
WB analysis of NCI-H460 and SK-BR-3 cell lysates (35ug/lane) using Cytokeratin 80 antibody.
Application Notes
WB : 1:1000
Additional Information
Form
Liquid
Storage Instructions
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide