| Product Name | DAG1 / alpha Dystroglycan antibody , N-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to alpha Dystroglycan (dystroglycan 1 (dystrophin-associated glycoprotein 1))Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human alpha Dystroglycan. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Predicted Reactivity | Human, Mouse, Rat, Dog, Cat, Rabbit, Rhesus Monkey, BovineHuman (100%), Mouse (90%), Rat (90%), Dog (92%), Cat (90%), Rabbit (88%), Rhesus Monkey (97%), Bovine (90%) |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | 156DAG antibody A3a antibody AGRNR antibody DAG antibody DAG1 antibody dystroglycan antibody dystroglycan 1 (dystrophin-associated glycoprotein 1) antibody |
|---|---|
| Molecular Weight(MW) | 97 kDa (note) |
| Cellular Localization | Alpha-dystroglycan: Secreted , extracellular space , Beta-dystroglycan: Cell membrane , Cytoplasm , cytoskeleton |
| Positive Control | Target recombinant protein |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
