Application
Western blot analysis of extracts from K562 cells untreated (lane 1) or treated with serum (lane 2) using DAXX (Phospho-Ser739) Antibody.| Product Name | Daxx (phospho Ser739) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Daxx (phospho Ser739)This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
| Immunogen | Peptide sequence around phosphorylation site of serine 739 (L-S-D-S(p)-D) derived from Human DAXX. |
| Modification | p-Ser739 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:500 - 1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | DAP6 BING2 EAP1 death-domain associated protein DAXX |
|---|---|
| Target | Daxx (phospho Ser739) |
| Tissue Specificity | The antibody detects endogenous level of DAXX only when phosphorylated at serine 739. |
Application
Western blot analysis of extracts from K562 cells untreated (lane 1) or treated with serum (lane 2) using DAXX (Phospho-Ser739) Antibody.| Application Notes | WB: 1:500 - 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C |
| Storage Buffer | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
