Rabbit Polyclonal antibody to DGCR2 (DiGeorge syndrome critical region gene 2)Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. [provided by RefSeq]
Immunogen
Recombinant protein encompassing a sequence within the center region of human DGCR2. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
*Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
Human
Predicted Reactivity
Mouse, Rat, BovineMouse (97%), Rat (97%), Bovine (90%)
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
DGS-C antibody, DKFZp686I1730 antibody, IDD antibody, KIAA0163 antibody, LAN antibody, SEZ-12 antibody, DGCR2 antibody, DiGeorge syndrome critical region protein 2 antibody, integral membrane protein deleted in DiGeorge syndrome antibody, integral membrane
Molecular Weight(MW)
61 kDa (note) (5)
Cellular Localization
Membrane; Single-pass type I membrane protein
Application
Application
Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE diluted at 1:1000
Application
Immunohistochemical analysis of paraffin-embedded human gastric cancer, using DGCR2 antibody at 1:500 dilution.
Positive Control
NT2D1 , IMR32 , MCF-7
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.