Rabbit Polyclonal antibody to DGUOKIn mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human DGUOK
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
WB 1:500 - 1:2000, IHC 1:50 - 1:200
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
deoxyguanosine kinase , dGK , MTDPS3
Target
DGUOK
Molecular Weight(MW)
32 kDa (note)
Application
Application
Western blot analysis of extracts of various cell lines, using DGUOK antibody.