Rabbit polyclonal antibody to DISC1 (disrupted in schizophrenia 1)This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human DISC1. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
C1orf136 antibody FLJ13381 antibody FLJ21640 antibody FLJ25311 antibody FLJ41105 antibody KIAA0457 antibody SCZD9 antibody DISC1 antibody disrupted in schizophrenia 1 protein antibody disrupted in schizophrenia 1 antibody
Target
DISC1
Molecular Weight(MW)
94 kDa (note) (22)
Cellular Localization
Cytoplasm , Centrosome , cytoskeleton
Application
Application
Sample(30 μg of whole cell lysate) A:MOLT4 7.5% SDS PAGE diluted at 1:1500
Positive Control
Molt-4
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
1XPBS, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.