Rabbit Polyclonal antibody to Dispatched A (dispatched homolog 1 (Drosophila))The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq]
Immunogen
Recombinant protein encompassing a sequence within the center region of human Dispatched A. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Predicted Reactivity
Human, Mouse, Rat, ZebrafishHuman (100%), Mouse (91%), Rat (92%), Zebrafish (80%)
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)