Application
Sample (50 ug of whole cell lysate) A: mouse testis 7.5% SDS PAGE diluted at 1:1000Application
Sample (30 ug of whole cell lysate) A: PC-3 B: U87-MG 7.5% SDS PAGE diluted at 1:1000| Product Name | DMTF1 antibody , Internal |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to DMTF1 (cyclin D binding myb-like transcription factor 1)This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human DMTF1. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
: |
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| Species Reactivity | HumanMouse |
| Predicted Reactivity | Chicken, Rhesus MonkeyChicken (89%), Rhesus Monkey (99%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | DMP1 antibody DMTF antibody FLJ25188 antibody FLJ41265 antibody FLJ76054 antibody hDMP1 antibody DMTF1 antibody cyclin D-binding Myb-like protein antibody hDMTF1 antibody cyclin-D-interacting Myb-like protein 1 antibody cyclin-D-binding Myb-like |
|---|---|
| Molecular Weight(MW) | 84 kDa (note) (3) |
| Cellular Localization | Nucleus |
Application
Sample (50 ug of whole cell lysate) A: mouse testis 7.5% SDS PAGE diluted at 1:1000
Application
Sample (30 ug of whole cell lysate) A: PC-3 B: U87-MG 7.5% SDS PAGE diluted at 1:1000| Positive Control | PC-3 , U87-MG , mouse testis |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
