| Product Name | DNase I antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to DNase IDeoxyribonuclease I (DNase I) is a Ca2+ and Mg2+ dependent endonuclease. DNase I is synthesized in the pancreas and stored in zymogen granules. It has been used to reduce the viscosity of cystic fibrosis sputum. A DNase I-like enzyme appears to catalyze the degradation of chromatin to oligo-and mononucleosomes during apoptosis. A recent study has demonstrated an endonuclease with activity and antigenicity indistinguishable from DNase I in thymocytes, cells susceptible to apoptosis. Deoxyribonuclease I (DNase I) is an endonuclease that hydrolyzes double-stranded or single-stranded DNA preferentially at sites adjacent to pyrimidine nucleotides. The product of hydrolysis is a complex mixture of 5' phosphate mononucleotides and oligonucleotides. In the presence of magnesium ion, DNase I attacks each strand of DNA independently and the cleavage sites are random. |
| Immunogen | Full length native protein (purified) (Cow). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: Use at a concentration of 1 μg/ml. Detects a band of approximately 33 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Bovine |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | DNASE1 DNase I 282217 |
|---|---|
| Target | DNase I |
| Cellular Localization | Nuclear |
| Application Notes | WB: Use at a concentration of 1 μg/ml. Detects a band of approximately 33 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.01% Sodium Azide; Constituents: PBS. pH 7.2 |
