Rabbit Polyclonal antibody to DNASE2B (deoxyribonuclease II beta)The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Immunogen
Recombinant protein encompassing a sequence within the center region of human DNASE2B. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
Human
Predicted Reactivity
BovineBovine (88%)
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
DLAD antibody DNASE2B antibody lysosomal DNase II antibody DNase2-like acid DNase antibody endonuclease DLAD antibody deoxyribonuclease-2-beta antibody DNase II beta antibody DNase II-like acid DNase antibody deoxyribonuclease II beta antibody
Molecular Weight(MW)
42 kDa (note) (2)
Application
Application
Sample (30 ug of whole cell lysate) A: HCT116 12% SDS PAGE diluted at 1:500
Positive Control
A549 , HeLa , HepG2 , HCT116
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.