Rabbit polyclonal antibody to Dopamine receptor D3The DRD3 Dopamine Receptor is expressed in brain regions associated with cognitive, emotional, and endocrine functions. DRD3 mediates the effects of drugs used in the treatment of schizophrenia and Parkinson's disease. DRD3 also binds BP897, a potent inhibitor of drug-craving and cocaine-seeking behaviors. Mutations in DRD3 lead to sodium retention in the kidney, resulting in hypertension and increased locomotor activity in mice. Multiple isoforms of DRD3 are produced by alternative splicing.
Immunogen
Synthetic peptide - KLH conjugated corresponding to 3rd cytoplasmic domain of human
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-P
We recommend the following starting dilutions: Immunohistochemistry-Paraffin 20 ug/ml. Optimal concentration should be determined experimentally by the end user.:
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
Drd1 Drd1a DRD3 1814 D(1A) dopamine receptor
Application
Application
Staining of Formalin-Fixed Paraffin-Embedded (FFPE) human Brain, cortex using
Application Notes
We recommend the following starting dilutions: Immunohistochemistry-Paraffin 20 ug/ml. Optimal concentration should be determined experimentally by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.