Rabbit polyclonal antibody to DR1This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
Immunogen
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the central region of human DR1.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB : 1:1000
Species Reactivity
HumanMouse
Concentration
0.5mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
NC2-BETA NC2 down-regulator of transcription 1 TBP-binding (negative cofactor 2)
Application
Application
WB analysis of K562 cell lysate (35ug) using DR1 antibody.
Application
WB analysis of mouse kidney tissue lysate (35ug) using DR1 antibody.
Application Notes
WB : 1:1000
Additional Information
Form
Liquid
Storage Instructions
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.