| Product Name | EGFR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [F4] to EGFREGFR is the prototype member of the type 1 receptor tyrosine kinases. EGFR is encoded by the cellular oncogene c-erbB-1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. EGFR over-expression in tumors indicates poor prognosis. EGFR over-expression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. |
| Immunogen | Synthetic peptide DVVDADEYLIPQ corresponding to aa 985-996 of human EGFR. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | F4 |
| Host Species | Mouse |
| Tested Applications | ELISAIHC-FIHC-PIPRIA |
| Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | EGFR P00533 ERBB1 131550 1956 ERBB mENA |
|---|---|
| Target | EGFR |
| Tissue Specificity | No reaction with erbB-2, erbB-3 and erbB-4. |
| Cellular Localization | Cell Membrane and Secreted |
| Light Chain Type | kappa |
| Application Notes | Optimal dilutions/concentrations should be determined by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate-buffered saline, no preservative added |
