Application
Application| Product Name | ERR gamma antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal to Human Estrogen - Related Receptor Gamma ( ERR Gamma / NR3B3 )Estrogen receptor-related receptor (ERR gamma), a NR3 Steroid Receptor, has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half-site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC-1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre-mRNA undergoes extensive alternative splicing at the 5a€(tm) end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development. ERR gamma expression at the mRNA and protein levels is isoform- and tissue-specific in humans. ERR gamma expression has been documented in human heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, prostate, testis, and small intestine. ESTs have been isolated from human tissue libraries, including cancerous fetus, uterus, lung, breast, head/neck, colon, skin, eye, adrenal, and breast, and normal placenta, kidney, brain, eye, pineal, ear, and heart. |
| Immunogen | Synthetic peptide - KLH conjugated |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIHC-P |
| Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses. IHC-P: Use at a dilution of 1/100 - 1/200.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | 2104 DKFZp781L1617 ERR3 ESRRG ERR gamma P62508 NR3B3 602969 |
|---|---|
| Target | ERR gamma |
Application
Application| Application Notes | Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses. IHC-P: Use at a dilution of 1/100 - 1/200.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate buffered saline, pH 7.4 containing 0.01% sodium azide |
