Application
Immunohistochemistry staining of ESRRG in kidney tissue using ESRRG Antibody.| Product Name | ESRRG Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ESRRG, ERR Gamma, ERR gamma-2, ERR3, Err-gamma, NR3B3, ERRG2, ERRgamma, KIAA0832 |
| Product description | Estrogen receptor-related receptor (ERR gamma), a NR3 Steroid Receptor, has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half-site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC-1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre-mRNA undergoes extensive alternative splicing at the 5’ end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development. |
| Immunogen | ESRRG antibody was raised against a peptide located in the N-Terminal domain of ESRRG (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| ESRRG antibody can be used in immunohistochemistry starting at 10 - 15 μg/mL.: |
|
| Species Reactivity | BatBovineDogGibbonGorillaHamsterHorseHumanMonkeyMouseOrangutanRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ESRRG |
|---|---|
| Alternative Names | ESRRG ERR Gamma ERR gamma-2 ERR3 Err-gamma NR3B3 ERRG2 ERRgamma KIAA0832 |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of ESRRG in kidney tissue using ESRRG Antibody.| Application Notes | ESRRG antibody can be used in immunohistochemistry starting at 10 - 15 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | ESRRG antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
