Application
Western blot analysis of recombinant ER alpha.| Product Name | Estrogen Receptor alpha antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [33] to Estrogen Receptor alphaThis gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008] |
| Immunogen | Synthetic peptide corresponding to the residues E(247) V G M M K G G I R K D R R G(261) of the ER alpha DNA binding domain. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 33 |
| Host Species | Mouse |
| Tested Applications | BlockingFACSGSAIEICC/IFIHCIHC-FIHC-PIPWB |
| IHC-P: 2-5ug/ml: |
|
| Species Reactivity | HumanMouseRatFishPrimateSheepBovineAvian |
| Concentration | 0.5mg/ml |
| Gene Synonyms | Era ESR estrogen receptor 1 ER NR3A1 ESR1 ESRA |
|---|---|
| Target | Estrogen Receptor alpha |
| Tissue Specificity | This antibody detects both the steroid occupied and unoccupied forms of the Estrogen Receptor alpha. It does not cross react with ER beta. |
Application
Western blot analysis of recombinant ER alpha.| Application Notes | IHC-P: 2-5ug/ml: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -20° C, Avoid Freeze/Thaw Cycles |
| Storage Buffer | Ascites containing 0.1 % sodium azide |
