Rabbit polyclonal antibody to Estrogen Receptor betaThis gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide corresponding to residues A(55) E P Q K S P W C E A R S L E H(70) of rat ER beta.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
FACSGSAICC/IFIHCIHC-FIHC-PIPWBChIP
ICC/IF: 1:40 - 1:500:
Species Reactivity
HumanMousePigRatHamsterPrimateSheepBovine
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
ESR-BETA ESR2 ESTRB ESRB ERB ER-BETA NR3A2
Target
Estrogen Receptor beta
Application
Application
IF using
Application
Immunolocalization of ER beta in primate amygdala using
Application Notes
ICC/IF: 1:40 - 1:500:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.