Application
Application| Product Name | Factor V Light chain antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [701] to Factor V Light ChainCoagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Defects in F5 are the cause of Owren parahemophilia which is an hemorrhagic diastesis. Defects in F5 are the cause of resistance to activated protein C (APCR). APCR is a form of thrombophilia. The APCR mutation is found in about 5% of the population which suggest that a slight thrombotic tendency may confer some advantage in fetal implantation. |
| Immunogen | Human Factor V Light Chain |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 701 |
| Host Species | Mouse |
| Tested Applications | ELISA |
| ELISA: Use at an assay dependent dilution. Autoradiography: Use at an assay dependent dilution. Could work well in IHC but has not been determined yet. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Synonyms | Factor V Light chain PCCF 2153 factor V FVL 227400 F5 P12259 |
|---|---|
| Target | Factor V Light chain |
| Cellular Localization | Secreted |
Application
Application| Application Notes | ELISA: Use at an assay dependent dilution. Autoradiography: Use at an assay dependent dilution. Could work well in IHC but has not been determined yet. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, no preservative added. |
