| Product Name | Factor XII Heavy chain antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [B7C9] to Factor XII heavy chainThis gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq] |
| Immunogen | Purified human Factor XII. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | B7C9 |
| Host Species | Mouse |
| Tested Applications | PurifyELISAInhibitionIPWB |
| Dilute in PBS or medium which is identical to that used in the assay system. This antibody partially blocks Factor XII activity.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Synonyms | Factor XII Heavy chain P00748 2161 HAF 234000 F12 |
|---|---|
| Target | Factor XII Heavy chain |
| Tissue Specificity | This antibody reacts with the heavy chain of human Factor XII (mw~50,000) with a KD of 9.8nM. |
| Application Notes | Dilute in PBS or medium which is identical to that used in the assay system. This antibody partially blocks Factor XII activity.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS, pH7.2 |
