| Product Name | Fas antibody (Azide free) |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [APO-1-3] to FasThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] |
| Immunogen | Recombinant human Fas. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG3 |
| Clone Number | APO-1-3 |
| Host Species | Mouse |
| Tested Applications | FACSIPWBFunctional Assay |
| Functional Assay: Induces apoptosis with or without cross-linking (Protein A), depending on cell type. Note: Optimal conditions must be determined.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | FASTM CD95 Fas cell surface death receptor APT1 FAS ALPS1A FAS1 TNFRSF6 APO1 |
|---|---|
| Target | Fas |
| Tissue Specificity | Recognizes human Fas. |
| Application Notes | Functional Assay: Induces apoptosis with or without cross-linking (Protein A), depending on cell type. Note: Optimal conditions must be determined.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20°C. |
| Storage Buffer | PBS. |
