Application
FACS ImageStaining of HUT78 T cell line with Mouse anti Human CD95:FITC| Product Name | Fas antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [LOB 3/17] to FasThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the tra |
| Immunogen | Fusion protein comprising extracellular domain of human Fas linked to human Fc. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | LOB 3/17 |
| Host Species | Mouse |
| Tested Applications | FACSIP |
| Flow Cytometry: 1/50 - 1/100: |
|
| Species Reactivity | HumanRhesus Monkey |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CD95 APT1 FASTM FAS1 ALPS1A APO-1 FAS TNFRSF6 |
|---|---|
| Target | CD95 |
| Tissue Specificity | This antibody recognizes human Fas, also known as CD95. |
Application
FACS ImageStaining of HUT78 T cell line with Mouse anti Human CD95:FITC| Application Notes | Flow Cytometry: 1/50 - 1/100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | TRIS buffered saline containing 0.09% Sodium Azide |
