Rabbit polyclonal antibody to FEZ2Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76. In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)-z substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-z, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-z in a tissue non-specific manner. FEZ2 can interact with FEZ1 through its c-terminal regions and especially its coiled-coil region. At least two isoforms of FEZ2 are known to exist.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAICC/IFWB
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
Fasciculation and elongation protein zeta-2, Fasciculation and elongation protein zeta2, FEZ2, zygin 2, zygin2
Target
FEZ2
Tissue Specificity
This antibody is specific for FEZ2 Internal
Application
Application
Immunofluorescence of human brain tissue using FEZ2 antibody at 5 ug/ml.
Application
Western blot analysis of FEZ2 in 3T3 cell lysate with FEZ2 antibody at (A) 0.5, and (B) 1 ug/ml.