Mouse Monoclonal Antibody [5C11A2] to FOXP2This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Immunogen
The immunogen corresponding to human MAPK3 expressed in E. Coli.
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
5C11A2
Host Species
Mouse
Tested Applications
ELISAWB
ELISA: 1/10000.:
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
TNRC10 SPCH1 CAGH44
Target
FOXP2
Molecular Weight(MW)
85 kDa (note)
Application
Application
ELISA analysis of control antigen and antigen using FOXP2 antibody [5C11A2].
Application
WB analysis of human FOXP2 (a.a. 47-287) recombinant protein using FOXP2 antibody [5C11A2].