Mouse Monoclonal antibody [8F12BB5] to FumaraseThe protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]
Immunogen
Purified proteins from bovine liver, bovine heart, porcine heart.
Key Feature
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
8F12BB5
Host Species
Mouse
Tested Applications
ICC/IFIHCIHC-PIP
ICC: 5 ug/ml:
Species Reactivity
HumanRatBovine
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Target Information
Gene Synonyms
MCL fumarate hydratase FH HLRCC MCUL1 LRCC
Target
Fumarase
Application
Application
IHC-P analysis of aged human cerebellar tissue using Fumarase antibody [8F12BB5].
Application
ICC/IF analysis of HDFn cells using Fumarase antibody [8F12BB5] at a concentration of 5 μg/ml (red) and DAPI (blue).