Application
Immunohistochemistry: GABA-RB Antibody [ - GABA-RB antibody (R328) [ - in paraffin-embedded human brain tissue| Product Name | GABA A Receptor beta 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to GABA A receptor beta 1GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Ralpha1-6, GABAA Rbeta1-3, GABAA Repisilon, GABAA Rdelta, GABAA Rgamma1-3, GABAA Rgamma1 and GABAA Rgamma2. The GABAB family is composed of GABAB R1alpha and GABAB R1beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHCIHC-P |
| We recommend the following starting dilutions: ELISA 1:40000-1:60000, immunohistochemistry 1:50-1:200. Optimal concentration should be determined experimentally by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | gammaaminobutyric acid A receptor MGC116903 alpha 6 GABA A gamma-aminobutyric acid (GABA) A receptor ant alpha6 GABA subunit A receptor alpha 6 MGC116904 GABA subunit A receptor alpha6 gamma-aminobutyric acid A receptor 2560 25450 GABRB1 256025 |
|---|---|
| Target | GABA A receptor beta 1 |
| Tissue Specificity | GABA-RB (R328) detects endogenous levels of GABA-RB protein. |
Application
Immunohistochemistry: GABA-RB Antibody [ - GABA-RB antibody (R328) [ - in paraffin-embedded human brain tissue| Application Notes | We recommend the following starting dilutions: ELISA 1:40000-1:60000, immunohistochemistry 1:50-1:200. Optimal concentration should be determined experimentally by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate buffered saline, pH 7.2. |
