Application
Various tissue extracts (50 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with GABA B Receptor 1 antibody diluted at 1:1000.| Product Name | GABA B Receptor 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to GABA B Receptor 1 (gamma-aminobutyric acid (GABA) B receptor, 1)Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of mouse GABA B Receptor 1. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | MouseRat |
| Predicted Reactivity | Human, Pig, BovineHuman (99%), Pig (98%), Bovine (97%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | GABA-B receptor 1 antibody GABA-B-R1 antibody GABA-BR1 antibody GABAB1 antibody GABAbR1 antibody Gabbr1 antibody Gb1 antibody bM573K1.1 antibody gamma-aminobutyric acid (GABA) B receptor 1 antibody |
|---|---|
| Target | GABA B Receptor 1 |
| Molecular Weight(MW) | 108 kDa (note) |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity) , Cell junction , synapse , postsynaptic cell membrane; Multi-pass membrane protein (By similarity) |
Application
Various tissue extracts (50 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with GABA B Receptor 1 antibody diluted at 1:1000.| Positive Control | mouse brain , rat brain |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
