Rabbit Polyclonal antibody to GARP2Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. GARPs are characterized by six repeated motifs of: V V E K K N/E E. These repeat motifs help form an alpha-helix structure. The function(s) of GARP have not been fully characterized, but studies have suggested that GARP helps limit cGMP turnover by inhibiting phosphodiesterase activity. To date, there have been two splice variants characterized: GARP1 (full-length GARP) and GARP2 (truncated GARP). GARP also interacts with part of the larger cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel found in the plasma membrane.
Immunogen
Synthetic peptide corresponding to residues C(287) D V Q T R V V A A G S L(299) of bovine GARP2.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
WB
WB: 1 ug/ml Optimal dilution / concentration should be determined by the end user.
Species Reactivity
HumanRatBovine
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
CNGB1, GARP
Target
GARP2
Application
Application
Western blot of GARP2 in rat purified rod outer membranes using
Application Notes
WB: 1 ug/ml Optimal dilution / concentration should be determined by the end user.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
PBS containing 1 mg/ml BSA and 0.05% sodium azide.