Application
Western blot analysis of GAS in EL4 cell lysate in (A) the absence and (B) the presence of blocking peptide with GAS antibody at 1ug/ml.| Product Name | GAS antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to GASSteroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERa), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERa is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | PTIPassociated1 protein, PTIP-associated 1 protein, PTIPassociated 1 protein, Glutamaterich coactivator interacting with SRC1, GAS, PA1, Glutamate-rich coactivator interacting with SRC1, PTIP associated 1 protein |
|---|---|
| Target | GAS |
| Tissue Specificity | This antibody is specific for GAS |
Application
Western blot analysis of GAS in EL4 cell lysate in (A) the absence and (B) the presence of blocking peptide with GAS antibody at 1ug/ml.| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
