| Product Name | GDNF antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to GDNFGlial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated, disulfide-bonded homodimer. It promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings, it has been suggested that GDNF may play a role in the treatment of Parkinson’s disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIP |
| Western blotting (0.5-4 µg/ml). Based on researcher’s feedback, the antibody also works in immunoprecipitation (10-20 µg/ml), and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes GDNF of human, mouse, and rat origins. Jurkat cell lysate can be used as a positive control. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Glial cell linederived neurotrophic factor, GDNF, Astrocytederived trophic factor, ATF, Astrocyte-derived trophic factor, ATF, Glial cell line-derived neurotrophic factor, neurotrophic factor GDNF |
|---|---|
| Target | GDNF |
| Tissue Specificity | This antibody is specific for GDNF. |
| Application Notes | Western blotting (0.5-4 µg/ml). Based on researcher’s feedback, the antibody also works in immunoprecipitation (10-20 µg/ml), and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes GDNF of human, mouse, and rat origins. Jurkat cell lysate can be used as a positive control. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Stored at -20 °C for future use. |
| Storage Buffer | PBS (pH 7.2) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal |
