Rabbit polyclonal antibody to GDNF Receptor alpha 1Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009]
Immunogen
Peptide from C terminus of human GDNF Receptor alpha 1
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIHC-PWB
Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user.
IHC analysis of human brain tissue using GDNF Receptor alpha 1 antibody.
Application
WB analysis of human brain (B), liver (L), kidney (K), spleen (S) tissue lysate using GDNF Receptor alpha 1 antibody.
Application Notes
Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user.
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.